Disbiose intestinal e obesidade na terceira infância: uma revisão integrativa

Abstract

Intestinal dysbiosis can trigger inflammation and pathologies such as obesity. This dysfunction can be installed in childhood, it can persist into adulthood. Therefore, we sought to conduct an integrative review to analyze the relationship between obesity and dysbiosis in the third stage of childhood. A literature search was conducted for articles published in the last 10 years in the PubMed, ScienceDirect, Scielo and LILACS databases using the descriptors: “dysbiosis”, “children”, and “obesity”. A total of 59 articles were initially found using the inclusion and exclusion criteria and 2 articles were selected to compose this study. These articles which deal with the relationship between changes in the intestinal microbiota of obese children, it was possible to identify that the studies made an association between different amounts of bacteria with the inflammatory obesity profile, diet types and anthropometric measurements. The data observed in the studies show that obese children presented intestinal dysbiosis and an increase in adiposity markers for the following genera and species: Dialister spp, Bilophila spp, Holdemania spp, Coprococcus catus, Paraprevotella xylaniphila, and L. reuteri, when associated with a nutritionally unbalanced diet, in turn contributing to advance childhood obesity. On the other hand, the L. paracasei species may be a protective factor against obesity. Therefore, there is evidence that intestinal dysbiosis observed in children’s microbiome has an impact on protective or risk-promoting functions in the development of childhood obesity. However, more studies are needed to understand whether dysbiosis is a cause or consequence of obesity, especially in Brazilian children.