Efeitos glicêmicos da dexmedetomidina associada ao tramadol e comparação da recuperação com ioimbina e atipamezol em felinos

Abstract

Α2 adrenergic agonist drugs are widely used as pre-anesthetic medication for cats. Dexmedetomidine is a representative of this group, which has high selectivity and specificity for α2-adrenergic receptors, ratio α2:α1 of 1600:1, providing sedation, analgesia and miorelaxation, with low respiratory depression and discrete cardiorespiratory alterations to felines. Among the endocrine effects is the reduction of circulating insulin, resulting in hyperglycemia. In turn, the ioimbine and atypamezol are medications that allow you to reverse the effects of α2-adrenergic agonists. The present study aimed at evaluating the glucose changes arising from the associated administration of dexmedetomidine and tramadol and comparison of recovery time of yohimbine and atypamezol in felines. For both, eight clinically healthy cats, without defined breed, had their blood glucose levels were evaluated and then submitted to combined sedation with dexmedetomidine (40μg/kg) and tramadol (2 mg/kg), both intramuscular. The patients were then anestesicamente induced with propofol (5mg/kg) intravenously for performing orchiectomy and submitted to local anesthesia by means of lidocaine with epinephrine (9 mg/kg) subcutaneously at the incision site and the spermatic. After 30 minutes of application of sedatives were applied medication to reverse the effects of dexmedetomidine: 4 cats of the DTI group received 0.1mg/kg yohimbine intravenously, while in other 4 animals of group DTA was administered 0.2mg/kg atypamezol intravenously. Immediately after the administration of the antagonists, the animals were positioned in the lateral decubitus and the periods of recovery were timed, no new measurement of glucose 5 minutes after the application of the Reversers. The glucose values observed after the application of dexmedetomidine and α2 adrenergic antagonists were statistically higher in relation to baseline values. The values expressed after the application of Atypamezol were statistically higher than those measured values after action of dexmedetomidine. Regarding the evaluation of anesthetic recovery, there was no significant difference in duration and quality between the groups DTA and DTI. These results demonstrate that the hyperglycemic effect of dexmedetomidine has not significantly exceeds the values hemostásicos and atypamezol and yohimbine have effective effects similar to the reversal of the sedative effects of dexmedetomidine.