Avaliação histológica imediata do sistema genital de cadelas submetidas a ovariosalpingohisterectomia

Abstract

Veterinary Medicine goes trough a great advance in the development of techniques that aim to control pain in surgical procedures, in which multimodal anesthesia, that consists of the use of analgesic drugs of several categories at reduced doses, is highlighted. Propofol is the drug most commonly used in veterinary medicine as a hypnotic agent. However, it is known that its isolated use in continuous infusion causes cardiorespiratory depression, but when it is associated with analgesic agents such as ultra short duration opioids (morphine or fentanyl), ketamine and lidocaine it is possible to decrease its rate of administration and the side effects on surgery time and hemostasis, which can lead to further tissue and vascular injuries in the genital system. These injuries can mean more postoperative discomfort. Evaluate these parameters, histological sections of the tissue fragments of ovaries, horns and uterine body removed from bitches are performed. Therefore, the present study had as purpose to evaluate histologically alterations of the genital system of bitches submitted to elective ovarian resection and anesthetized with propofol and continuous infusion of morphine or fentanyl, associated with ketamine and lidocaine. Twenty adult healthy dogs were selected, aged 3-6 years and middle weight of 12.4kg; from the Animal Protection Association of Feira de Santana-Bahia, divided into two groups FLK (fentanyl, lidocaine and ketamine) and MLK (morphine, lidocaine and ketamine). After each surgery, the ovaries, horns and uterine body were collected, which were submitted to fixation, dehydration, clarification, impregnation, inclusion and paraffin embedding, microtome cutting, staining and finishing with histological slide assembly. The data were analyzed by the statistical analysis program SisvarTM. At the end of the histological evaluation of the reproductive system of bitches submitted to ovariossalpingohisterectomy, it was observed that in the GFLK a smaller number of animals presented injuries (prevalence rate) and less intensity (level of severity) when compared to GMLK, having as parameters: hemorrhage (70% and 100 %), edema (10% and 60%) and tissue distress (70% and 80%), respectively. Thus, within the conditions of this experiment, it is suggested that GFLK protocol is more efficient in the control of pain, based on the parameters evaluated.